Check out how easy it is to complete and eSign documents online using fillable templates and a powerful editor. i was expecting more "evacuation". Consume at least five 8. — Then drink at least 40 oz. Magnesium citrate is mild when used in the recommended amounts. What’s in the CLENPIQ box? To learn more visit CLENPIQ. Prep day you'll want to be home, the day of the procedure, and the day after to recover from sedation cause you'll still feel yucky. Common side effects of Clenpiq include nausea, headache, and. Do not take oral medications within one hour of starting CLENPIQ. Drink an additional 5 (8 ounce) glasses (total of 40 ounces) of water, at your own pace, within the next 2 hours. 8 and incline on number 1. Studies usually compare a. As soon as your colonoscopy is over, we stop the IV medicine, and you. long walks, and my girlfriend! Here you’ll find simple and delicious recipes. No nausea or vomiting occurred. – 12 a. By 930 I finally had some movement - drank drank drank. Finish liquids 2 hours before your colonoscopyCLENPIQ can reduce the absorption of co-administered drugs. • 5 hours before your check-in time take 2nd dose of CLENPIQ. 1) •Two doses of CLENPIQ are required for a complete preparation for colonoscopy as a Split -Dose regimen. • Do not drink alcohol. CLENPIQ is a clear liquid that may have. Of these 2652 lots, only 18% were terminated due to failure. You may drink more if you choose. Reviews and ratings for Clenpiq. In the split-dose regimen, half the total dose of the bowel cleansing agent is used the evening before your colonoscopy and the 2 nd half is used 4 hours before your colonoscopy. 4 ounces. POST-PROCEDURE • After the colonoscopy, you will remain in the recovery area for about 30 minutes until the effects of the sedating medication wear off. Uses Sodium picosulfate/ magnesium oxide /citric acid solution is used to clean out the intestines before surgery or certain procedures (such as. com. CLENPIQ is supplied in a carton containing two bottles, each holding 175 mL of cranberry-flavored, colorless to slightly yellow, clear oral solution with possible presence of visible particles. Studies have shown that split dose preps (in which laxatives are taken the evening before and the morning of the procedure) produce better cleansing. Digestive secretions will continue to "tint" the stool yellow. Do not refrigerate or freeze CLENPIQ. It works by removing ammonia from the body, which can help reduce symptoms associated with high levels of ammonia. Dulcolax and Miralax: The day before your colonoscopy, around 1pm, you take 4 Dulcolax (or store brand) tablets. The prep started to work before I finished the 32 oz of water. If you feel nauseous - slow down, relax, and sip. I took my first dose at 6:15 pm and the prep started working. Abdominal pain Abdominal pain included reports of abdominal pain, abdominal pain upper, and abdominal pain lower. Studies have shown that split dose preps (in which laxatives are taken the evening before and the morning of the procedure) produce better cleansing. 63, 95% confidence interval [CI] 0. Reviews and ratings for Clenpiq. Do I still need the rest of the prep? Yes, you may have solid stool higher in the colon that needs to be eliminated. , you would need to mix a product called Gavilyte or Colyte. How Long For Clenpiq To Take Effect. It peaks within 60 minutes, and its effects. Of course results may vary. No mixing is required. Again. 4 oz each) An 8 oz cup for drinking . 288 reviews submitted with a 5. Is there anything I need to do to make Clenpiq work faster? No, the onset of action is primarily dependent on your body’s natural response. 64; p<. Get everything done in minutes. Call your doctor for medical advice about side effects. CLENPIQ may affect how other medicines work. Make sure to take plenty of fluids throughout the day in addition to the fluids used for your bowel preparation. 5-3 hours (time from check-in to check-out). • Do not take other laxatives while taking CLENPIQ. The goal of the prep for colonoscopy is to completely rid your body of food particles. It usually takes about 30- 60 minutes after drinking the solution to begin having bowel movements. Polyethylene glycol 3350 (PEG), an osmotic laxative that cleanses out your bowels by pulling water into your colon and causing you to have very watery diarrhea to get rid of the stools. Pronunciation of CLENPIQ with 1 audio pronunciations. One dose (1 bottle) is taken twice before a colonoscopy. bottle at _____AM. Uses Clenpiq is prescribed. 7408 Main Office 1907 Highway 35, Suite 1 Oakhurst, NJ 07755 Colonoscopy 2 Day Prep Instructions – CLENPIQ AM (arrivals 6:30am - 11:30am)1. 8380 • 586. Once the MiraLAX is dissolved, you can put the mixture in the refrigerator. ACCEPTABLE CLEAR LIQUIDS FOR HYDRATINGIf that doesn't work, drink the second part of your prep and continue to drink fluids. 1627When users ask the question, “How long does colonoscopy prep take to work?” they should consider which brand they’re using first. View Free. I drank the 2nd bottle Clenpiq at 9pm. I’ve done the Miralax prep before and it was way way better. There is no reason to think that PrEP medications instantly become ineffective on the expiry date, but there is no way to know how long they may remain effective after that. This means you need at least 3 liters of fluid (bowel cleansing agent and clear liquid diet) to be clear. 2. Can you pronounce this word better. So what is the use of Clenpiq, how to use it and how to use it, and learn through the article below. It does not need to be mixed or diluted. and drink one 8-ounce glass every 15 minutes until you have consumed half the container. 2. Please follow recommendations for the 3 days prior and the 1 day prior. It really depends on what time this happens. Satisfaction. The preps used for split dose preps are Plenvu, Osmoprep Tablets, Clenpiq, and Suprep. Clenpiq is a combination of picosulfate and magnesium, so a stimulant and osmotic, which may cause some cramping. Long story short, I had a miserable night NOT pooping, and had to make multiple calls to the GI's office, and multiple trips to the. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. com. Have you tried enemas or suppositories? It may help to soften the stool-especially if you do an enema with a little mineral oil. (2. However, this can vary depending on individual factors such as age, body weight, and metabolism. It is difficult to predict how long the effects of clenpiq will last because it depends on many factors, including the individual’s. This article will discuss how long it takes for Clenpiq to wear off and any factors that might affect its duration. I realized the ClenPiq is also a stimulant laxative and now I'm wondering if I'll have the same fate either way. Approval: 2012Google the miralax ducolax prep and do your own. The prep may take up to 4 hours toDose 1 – THE DAY BEFORE THE COLONOSCOPY: Take the first dose (1 bottle) of CLENPIQ during the evening before the colonoscopy (eg, 5:00 to 9:00 pm). Stop iron, including medications or vitamins that contain iron. Mi x the remaining MiraLAX with a 2nd 32-ounce bottle of Gatorade and refrigerate for tomorrow. 1 out of 10 from a total of 1602 ratings on Drugs. Patent expiration dates: June 23, 2034. Of course, there are always exceptions. )Division of Gastroenterology . It does not need to be diluted prior to administration. This means you are asleep during the procedure. This office can be reached at 410-677-6654. On the day before the clinical procedure, you can eat a light breakfast followed by a light lunch. I'm debating paying out of pocket for clenpiq. So I have my first colonoscopy and endoscopy tomorrow. And as far as taste goes, I don't like Gatorade in general any better than. I could not taste it because I held my nose but this entire thing takes way too long. CLENPIQ can reduce the absorption of co-administered drugs. Do not refrigerate or freeze CLENPIQ. Clenpiq, accompanying clear liquids, and a sip of water with medication as instructed above. 1) Two doses of CLENPIQ are required for a complete preparation for colonoscopy as a Split-Dose regimen. Please read carefully 10 days before your procedure. CLENPIQ can reduce the absorption of co-administered drugs. How long will the colonoscopy take/how long will I be at the facility? The procedure itself takes about 30-45 minutes, however, plan on being at the Surgery Center for approximately 2. Clenpiq is a medication commonly used to cleanse the bowels before certain medical procedures. CLENPIQ is a prescription medicine that cleans your colon. 47% of reviewers reported a positive experience, while 40% reported a negative experience. I’m getting a colonoscopy tomorrow at 12:30. After taking Clenpiq, it typically takes about 30 minutes to 1 hour for the medication to start working. Take one of the Ondansetron tablets. If you are successfully enrolled in the Clenpiq patient assistance program, we will also request your Clenpiq medication refills on your behalf for up to 1 year. Just before 5, I drank the first bottle of Clenpiq. Suprep Bowel Prep Kit has an average rating of 7. 311 E 79th St. com. If you cannot get the stool to budge you may need. Some things I learned to make it easier: 1. Clenpiq. Should I drink Clenpiq slowly? 4. Turn right into. , Suite C, Mitchel Field, Uniondale, NY 11553 Phone: 516. Immediately follow with 40 ounces of water over the next hour. The Patient Medication Guide and the . 8 oz LIQUIDS MUST NOT BE RED OR PURPLE. You can reach Your Patient Advisor with non-medical prep questions at: 800. (2. But if you reach 50, welcome to the beginning of old age, where icky things start to happen to you. Prepopik side effects (more detail)Official answer. I barely made it through the 40-minute ride to the colonoscopy center. Two days before, the person will need to start drinking extra water, after which most people. I was given Plenvu as my bowel prep. Tell your doctor about all other medications (including prescription and nonprescription medicines, vitamins, and herbal supplements) you take before you take PLENVU®. If severe bloating, distention, or abdominal pain occurs. A PEG-based bowel prep may take one to three hours, while a NaP-based bowel prep may take three to six hours to start. However, this can vary depending on individual factors such as age, body weight, and metabolism. It peaks within 60 minutes, and its effects last for 3 to 5 hours. If you take any of the following medicines, take them at least 2 hours before or not less than 6 hours after you take Clenpiq: Satisfaction. Eating a low-residue, soft diet for a day or more before starting the prep can help make it easier and faster. m. Do not take oral medications within one hour of starting CLENPIQ. Six hours before the scheduled time of your procedure, drink another bottle of clenpiq. 517. Clenpiq tastes like a cranberry-flavored solution with a mild salty aftertaste. It's used to treat constipation and acid indigestion. . The reason behind this is because testing for actual shelf life of manufactured products will take a long time and costs a lot of money. IF YOU ARE ON BLOOD. LAXATIVE PREP INSTRUCTIONS. If taking tetracycline or fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, or penicillamine, take these medications at least 2 hours before and not. Factors that Affect the Duration of Clenpiq Wear OffClenpiq is an innovative medical testing solution designed to streamline the process of testing for renal function. Prep outcome was excellent (like yours). headache. 5-L bottles the morning of. I am taking the prep and already have loose, watery stools. CLENPIQ. When it comes to bowel preparation, Clenpiq is undoubtedly the champion. What am I in for tonight, toilet…Clenpiq is a medication used to help treat high levels of ammonia in the blood. If you have any questions, please feel free to call your doctor’s office. At 11pm it started to work I had a few explosive watery diarrheas, went to sleep at 2am. − Continue drinking clear liquids up until you go to bed. Prepare Your MiraLAX Bowel Preparation. These 3 medications work together to clean out the colon. Pour out about 8 oz. trouble swallowing, trouble drinking liquids. My first time was harder then my second time. but it did not work for me. 8. CLENPIQ may affect how other medicines work. m. Clenpiq and Suprep are both medications used to cleanse the bowel before a colonoscopy. My first movement was 75 minutes later, for reference, so you have a bit of mobility I'd say for the first hour. Drink second bottle of CLENPIQ. Check your blood sugar in the morning, and prior to traveling to the endoscopy lab. Please. This is a review on MY EXPERIENCE on taste and results of using this product. Instead my doc prescribed the prep ClenPiq, a low-volume bowel prep that wasn’t covered by my insurance and cost $100 out of pocket even after the $40 manufacturer’s coupon was applied!! Nonetheless, I am dreading the prep for this colonoscopy—not because of the. The bowel prep includes a strong laxative and liquid diet. 50% of reviewers reported a positive effect, while 39% reported a negative effect. 91, P=0. Can I drink all of my prep the night before instead of waking up early in the morning to drink the 2nd half? No. CLENPIQ ™ COLONOSCOPY PREP. 8 out of 10 from a total of 279 reviews for the treatment of Bowel Preparation. cups of clear liquid within the next 2 hours. CLENPIQ cleans your colon by causing you to have diarrhea. Satisfaction. While many people let anything having to do with. Dr Farmer outlines the proper procedures for Colonoscopy Preparation using Clenpiq. You may return to work or school the day after your examination unless otherwise specified by your surgeon. Call the office of the doctor who is doing your colonoscopy and ask them about it. ) Make sure you have 2 if possible 3 full days off work. The prep started to work before I finished the 32 oz of water. 21. Commonly reported. GaviLyte-C side effects. You take the first 6-ounce ounces bottle of CLENPIQ the evening before your. How long does it take a colonoscopy prep to clear bowels completely? It can take 12 to 16 hours for the bowels to completely clear. 9 out of 10 from a total of 228 ratings on Drugs. PLENVU® may affect how other medications work. Typically, bowel prep medication is a solution that you will need to drink starting one day before your procedure. Still cleaned me out though. The second dose of prep should be finished 4 hours prior to arrival. The procedure went well, it was noted that the quality of the bowel preparation was excellent :-). I barely made it through the 40-minute ride to the colonoscopy center. 09 ± 1. Then follow up with a cup of water every hour for six hours. 001) had higher total. However, in general, it is thought that clenpiq (a medication used to treat diabetes) takes around 2-4 weeks to start working effectively. Mix the 8. You need to stay hydrated throughout the process. Tastes like chemicals, so foul, nasty and vile. If you are severely constipated and your bowel movements aren’t progressing, contact your healthcare provider. 1. You take the first 6-ounce ounces bottle of CLENPIQ the evening before your colonoscopy at 5:00 PM. 2. Appropriate studies have not been performed on the relationship of age to the effects of Clenpiq® and Prepopik® in children younger than 9 years of age. Generally, people need to spend 30-60 minutes in the bathroom. The active ingredient in Clenpiq is sodium picosulfate. 8 out of 10 from a total of 288 ratings on Drugs. An option that can be purchased without a prescription is Miralax liquid and Dulcolax tablets, often taken together. Get. Don’t stop drinking the colonoscopy prep until it’s gone. • 4 hours before you plan on leaving forHow does Clenpiq Solution work? Clenpiq Solution works by flushing out the contents of the colon, making it easier for doctors to see any abnormalities during the procedure. Since you will. • Consume only clear liquids (no solid food) from the start of CLENPIQ treatment until after the colonoscopy. CLENPIQ is a clear liquid that may have particles. Clenpiq has an average rating of 5. On the con side, it tastes horrible! I couldn’t get all of the second bottle down. Osmoprep tablets and Suprep should not be used if you have heart or kidney problems. UCLA Health: Center for High Quality Health Care ServicesThis article will discuss how long it takes for Clenpiq to wear off and any factors that might affect its duration. Instead my doc prescribed the prep ClenPiq, a low-volume bowel prep that wasn’t covered by my insurance and cost $100 out of pocket even after the $40 manufacturer’s coupon was applied!! Nonetheless, I am dreading the prep for this colonoscopy—not because of the overnight. Still take the second dose at 10pm. Call us today at 1-866-779-7587. gelatin, such as Jell-O. lunar_languor • 1 yr. Drink the 2nd 160 ml bottle of Clenpiq. 2. Make sure to take plenty of fluids throughout the day in addition to the fluids used for your bowel preparation. It does not need to be mixed or diluted. Save on your Clenpiq prescription. How long will the colonoscopy take/how long will I be at the facility? The procedure itself takes about 30-45 minutes, however, plan on being at the Surgery Center for approximately 2. At _____, Drink One (1) bottle of CLENPIQ. Each packet is mixed with cold water (5 ounces) for 2 to 3 minutes and taken at separate times. Food and Drug. Drink at least 3 8oz cups of clear liquid. Any feedback is appreciated! i did clenpiq for my last one and i mean i dont like any prep but it is less liquid to drink so that might work out better for you it’s two small bottles and the rest is water. The present invention provides a physically and chemically stable pharmaceutical liquid composition including sodium picosulfate, magnesium oxide, citric acid and malic acid and methods of making and using such a composition. Moderate. Description and Brand Names. • CLENPIQ can reduce the absorption of co-administered drugs. 794. The day of your procedure: Six hours before your scheduled procedure (or 4 am if yourClenpiq has an average rating of 5. How long for clenpiq to take effect. Difficult. You will need to follow with 4 more 8 ounce glass of clear liquids. Polyethylene Glycol 3350 And Electrolytes (Oral Route) Polyethylene glycol (PEG) and electrolytes combination solution is used to cleanse the colon (bowel) before certain medical tests (eg, colonoscopy, barium enema X-ray exam) or colon surgery. . In this trial, CLENPIQ patients were instructed to drink at least five 8-ounce glasses of clear liquid within 5 hours of the first dose of CLENPIQ and at least four 8-ounce glasses of. I have my first colonoscopy scheduled and trying to decide which prep to use. Following the CLENPIQ, drink at least 40 ounces (equals 5 cups) of water within one (1) hour. Drink ALL the liquid fin the bottle. muscle pain or cramps. Safety and efficacy have not been established. Very difficult. When you finish the last half of the CLENPIQ prep solution, you should pass clear liquid from rectum. It’s important to use the method that’s likely to work best for you. com. the evening before your procedure: Start CLENPIQ • Drink one bottle of CLENPIQ followed by • Drinking 5 or more 8 (oz) cups of clear liquid. You may flavor with Crystal Light-Yellow Lemonade. CLENPIQ is ready for you to drink right from the bottle. How does clenpiq work. 288 reviews submitted with a 5. 8 average score. THREE DAYS BEFORE PROCEDURE What do I need to do THREE DAYS before the procedure? Pick up the PREPARATION SOLUTION from the pharmacy. (Seizures: Use caution in patients with a history of seizures. Introduction On January 31, 2017, Ferring Pharmaceuticals Inc. • 2 yr. 5. 1868 Fax: 516. Stop Plavix. Taking prescription Clenpiq in preparation for colonoscopy. Should this be concerning?. If you think you can’t drink your colonoscopy prep, a “split-dose” is a good option because it tends to be more tolerable. 004), and Miralax® with Gatorade® (7. Two days before, the person will need to start drinking extra water, after which most people. Make sure you’re at home and near an unoccupied bathroom. Long-term studies in animals to evaluate carcinogenic potential or studies to evaluate mutagenic potential have not been performed with CLENPIQ. However, the colon needs time to recover from the procedure and the preparation for it. "Paid $90 with insurance for Clenpiq. I just had a colonoscopy and had the same experience as you -- running clear after first round so I wanted to skip the second round in the wee hours of the morning. FIRST DOSE: You will begin your first dose of Clenpiq the evening before at (Please contact GI MD). No more Dulcolax and no more gallon of goo to be consumed. Uses Sodium picosulfate/ magnesium oxide /citric acid solution is used to clean out the intestines before surgery or certain procedures (such as colonoscopy, X-rays). My Dr has his patients take 4 tablets every 10 minutes using 16 oz of water over the 1st 30 mimutes, then wait 30 minutes before starting to drink the next 32 oz of water. Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine and penicillamine, at least 2 hours before and not less than 6 hours after administration of CLENPIQ to avoid chelation with magnesium. 212-996-6633 212-826-3903 212-535-1845 212-369-2490 718-280-0020 212-721-2600 Page 2 of 2 Preparation Instructions: Clenpiq & Magnesium CitratePrepare Your MiraLAX Bowel Preparation. But if you reach 50, welcome to the beginning of old age, where icky things start to happen to you. Four and a half hours before your colonoscopy on the day of your procedure: Drink an 8-ounce glass of bowel preparation every 10 minutes for a total of 8 glasses. Drink all the liquid in the container. CLENPIQ is a prescription medicine that cleans your colon. For bowel cleansing, Suprep® (7. Clenpiq is a prescription medicine used as bowel preparation in preparation for Colonoscopy. At 11pm it started to work I had a few explosive watery diarrheas, went to sleep at 2am. Clenpiq belo. It’s a split-dose regimen, where you take one dose between 4-6 pm the evening before your procedure, and the second dose. At 9 pm - Drink 1 bottle (160 ml) of CLENPIQ. Based on stability data, expiration dates on 88% of the lots were extended beyond their original expiration date for an average of 66 months. The box of prescription drugs had been forgotten in a back closet of a retail pharmacy for so long that some of the pills predated the 1969 moon landing. pinpoint red or purple spots on the skin. FIND US: Surrey, BC, Canada #109–7938 128th Street V3W 4E8. Drink CLENPIQ right from the bottle. I was told to start at 6pm, but I started at 5pm. Tastes like chemicals, so foul, nasty and vile. You may report side effects to FDA at 1-800-FDA-1088. Can you drink Clenpiq cold . Use the cup provided in the box. While my experience in taking CLENPIQ was fairly typical, you may require different dosing than was prescribed to me. LONG ISLAND CENTER FOR DIGESTIVE HEALTH 106 Charles Lindbergh Blvd. Do not take oral medications within one hour of starting CLENPIQ. , submitted an original 505(b)(2) new drug application (NDA) for Clenpiq, NDA 209589, based on the listed drug (LD), Prepopik (NDA 202535). • Follow CLENPIQ by drinking five or more 8- ounce cups (cup provided) of clear liquids within 5 hours and before bed. Six (6) hours before procedure, drink the other bottle of CLENPIQ – directly from the bottle. These physicians, some of whom work in house, closely with the staff, and others who are remote and readily available for a phone call or video chat, are liable for what happens within the facilities they oversee. Clenpiq belongs to a group of drugs called laxatives. See full prescribing information for CLENPIQ. 16 E 52nd St. Sodium picosulfate was not mutagenic in the Ames test, the mouse lymphoma assay,. STEP 1 Open 1 bottle of 12 tablets. long, flexible instrument that has a light and a camera at the tip, will be passed through the rectum and around the colon. CLENPIQ. Safely buy Clenpiq at our Canadian International Pharmacy Association (CIPA) certified online drugstore. Instructions for Use for your reference. A PEG-based bowel prep may take one to three hours, while a NaP-based bowel prep may take three to six hours to start. It starte d to work immediately about 10 minutes after taking the first dose with no belly pain just urgency to go. One bottle of CLENPIQ is equivalent to one dose. Moviprep or Clenpiq. Be gin drinking the 1st bottle of Gatorade with MiraLAX. Drink at least 24 oz (3 cups) of clear liquids. PEG-electrolyte solution is a laxative. Call your doctor at once if you have:These medications work by causing watery diarrhea so that the stool can be emptied from the colon. Approximately 2 1/2 hours after those 1st tablets. LEARN MORE About Clenpiq Improved Insurance Coverage Simple. Drink the entire first bottle of CLENPIQ. Do not take oral medications within one hour of starting CLENPIQ. • Do not eat solid food or dairy and do not drink anything colored red or purple. CLENPIQ is contraindicated in the following conditions: patients with severe reduced renal impairment (creatinine clearance less than. Based on stability data, expiration dates on 88% of the lots were extended beyond their original expiration date for an average of 66 months. ago. Beginning at least 5 hours prior to your procedure start time, drink the 2 nd dose of Clenpiq right from the bottle. Follow the instructions for days before, on the day of and after your colonoscopy, including medications, supplements and clear liquids. It is important to note that there is no one definitive answer to this question as it depends on a variety of individual factors. Felt nauseous trying to drink it. and staying there for a long time. com. I requested not to be given the dulcolax/miralax prep because I took dulcolax once (2 tablets) about six months ago and almost called 911. Just took my first bottle down of Clenpiq and have a bottle of water chasing it down. (4 votes) Very easy. There’s no mixing, and one bottle (or serving) has only 5. Bowel. bottle of preparation solution. At 7pm I took Dulcolax suppository. In the split-dose regimen, half the total dose of the bowel cleansing agent is used the evening before your colonoscopy and the 2 nd half is used 4 hours before your colonoscopy. I feel a lot of energy at work at home and daily spending time in the kitchen cooking for my family’s dinner, packing lunches for work, I feel happy & pain free it is amazing to feel no more pain, of anything my sugar levels are normal, I Exercise daily for only 1 hour of walking on the treadmill on speed number 2. This prep may cause multiple bowel movements within 30-60 minutes and may take as long as three (3) hours. Follow the ClenPiq prep with 5 glasses (8-ounces) clear liquid drinks using the cup supplied in the kit ~Do not plan to go anywhere after you have started drinking the prep. 05). Finish liquids. Take one of the Ondansetron tablets. Most of the time, people begin to have bowel movements about 3 hours after drinking the solution, so if a person has. Do not take oral medications within one hour of starting CLENPIQ. • You will need a driver to return home. November 21, 2019. and lab work. Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine and penicillamine, at least 2 hours before and not less than 6 hours after administration of CLENPIQ to avoid chelation with. . S.